Publications

2022

Young, L.EA., Conroy, L.R., Clarke, H.A., Hawkinson, T.R., Bolton, K.E., Sanders, W.C., Chang, J.E., Webb, M.B., Alilain, W.J., Vander Kooi, C.W., Drake, R.R., Andres, D.A., Badgett, T.C., Wagner, L.M., Allison, D.B., Gentry, M.S., Sun, R.C. (2022). In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues.  revision at EMBO Molecular Medicine.

 

Kinslow, C.J., Kumar, P., Cai, L.L., Sun, R.C., Chaudhary, K.R., Cheng, S.K. (2022). NRF2-Pathway Mutations Predict Radioresistance in NSCLC. Translational Lung Cancer Research. In Press

 

Valenca, S.S., Dong, B.E., Gordon, E.M., Sun, R.C., & Waters, C.M. (2022). ASK1 Regulates Bleomycin-Induced Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology. (Full Article).

Conroy, L.R., Allison, D.B., Sun, Q., Valenca, S.S., Young, L.EA., Clarke, H.A., Hawkinson, T.R., Ferreira, J.E., Hammonds, A.V., McDonald, R.J., Absher, K.J., Dong, B.E., Alilain, W.J., Gentry, M.S., Liu, J., Waters, C.M., Sun, R.C. (2022). Integration of Spatial Metabolomics and Machine Learning Reveal Glycogen as an Actionable Target for Pulmonary Fibrosis. Under Review- Cell Metabolism. (Full Article).

 

Xiao, M., Wu, C-H., Meek, G., Kelly, B., Young, L.EA., Martire, S., Castillo, D.B., Saha, P., Dube, A.L., Gentry, M.S., Banaszynski, L.A., Sun, R.C., Kikani, C.K. (2022). A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate. bioRxiv. (Full Article).

 

Xiong, X., Hasani, S., Young, L.EA., Rivas, D.R., Skaggs, A.T., Martinez, R., Wang, C., Weiss, H.L., Gentry, M.S., Sun, R.C., Gao, T. (2022). Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer. Cell Death & Differentiation, pp.1-15. (Full Article).

Conroy, L.R., Chang, J.E., Sun, Q., Clarke, H.A., Buoncristiani, M.D., Young, L.EA., McDonald, R.J., Liu, J., Gentry, M.S., Allison, D.B., Sun, R.C. (2022). High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity. Advances in Cancer Research. (Full Article)

Valenca, S.S., Dong, B.E., Gordon, E.M., Sun, R.C., Waters, C.M. (2022). ASK1 Regulates Bleomycin-Induced Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology(Full Article)

Hawkinson, T.R., Sun, R.C. (2022). Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Glycogen In Situ. Methods in Molecular Biology. 2437, 215-228. (Full Article).

2021

 Hawkinson, T.R., Clarke, H.A., Young, L.EA., Conroy, L.R., Markussen, K.H., Kerch, K.M., Johnson, L.A., Nelson, P., Allison, D.B., Gentry, M.S., Sun, R.C. (2021). In situ glycomic analysis of mouse and human brains of Alzheimer’s disease. Accepted Alzheimer’s & Dementia(Full Article)

Noe, J.T., Rendon, B.E., Geller, A.E., Conroy, L.R., Morrissey, S.M., Bruntz, R.C., Kim, E.J., Wise-Mitchell, A., Barbosa de Souza Rizzo, M., Relich, E.R., Baby, B.V., Johnson, L.A., Affronti, H.C., McMasters, K.M., Clem, B.F., Gentry, M.S., Yan, J., Wellen, K.E., Sun, R.C., Mitchell, R.A. (2021). Lactate supports a metabolic-epigenetic link in macrophage polarization. Science Advances, 7(46). (Full Article)

Conroy, L.R., Hawkinson, T.R., Young, L.EA., Gentry, M.S., Sun, R.C. (2021). Emerging roles of N-linked glycosylation in brain physiology and disorders. Trends in Endocrinology & Metabolism. (Full Article)

Andersen, J.V., Skotte, N., Christensen, S., Polli, F., Shabani, M., Markussen, K., Haukedal, H., Westi, E., Castillo, M., Sun, R.C., Waagepetersen, H.S. (2021). Hippocampal Disruptions of Synaptic and Astrocyte Metabolism are Primary Events of Early Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer's Disease. Cell Death and Diseases. (Full Article)

Farmer, B.C., Williams, H.C., Devanney, N.A., Piron, M.A., Nation, G.K., Carter, D.J., Walsh, A.E., Khanal, R., Young, L.EA., Kluemper, J.C., Hernandez, G., Allenger, E.J., Mooney, R., Golden, L.R., Smith, C.T., Brandon, J.A., Gupta, V.A., Kern, P.A., Gentry, M.S., Morganti, J.M., Sun, R.C., Johnson, L.A. (2021). APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis. Molecular Neurodegeneration.  (Full Article)

Gentry, M.G., Markussen, K.H., Sun, R.C., Vander Kooi, C.W. (2021). Treatment of Lafora disease with an antibody-enzyme fusion. Jasper's Basic Mechanisms of the Epilepsies 5th edition. In Press. 

 

Conroy, L.R., Allison, D.B., Sun, Q., Young, L.EA., Hawkinson, T.H., Clarke, H.A., Ferreira, J.E., Hammonds, A.V., McDonald, R.J., Absher, K.J., Alilain, W.J., Waters, C.M., Liu, J., Sun, R.C. (2021). Multi-Dimensional Reduction Clustering of Complex Carbohydrates Reveal Tissue Metabolism, Heterogeneity and Histopathology. bioRxiv.  (Full Article)

Conroy, L.R., Stanback, A.E., Young, L.EA., Clarke, H.A., Austin, G.L., Liu, J., Allison, D.B., Sun ,R.C. (2021). In situ analysis of N-linked Glycans as Potential Biomarkers of Clinical Course in Human Prostate Cancer. Molecular Cancer Research. (Full Article)

Sun, R.C., Young, L.EA., Bruntz, R.C., Markussen, K.H., Zhou, Z., Conroy, L.R., Hawkinson, T.R., Clarke, H.A., Stanback, A.E., Macedo, J.KA., Emanuelle, S., Brewer, M.K., Rondon, A.L., Mestas, A., Sanders, W.C., Mahalingan, K.K., Tang, B., Chikwana, V.M., Segvich, D.M., Contreras, C.J., Allenger, E.J., Brainson, C.F., Johnson, L,A,, Taylor, R.E., Armstrong, D.D., Shaffer, R., Waechter, C.J., Vander Kooi, C.W., DePaoli-Roach, A.A., Roach, P.J., Hurley, T.D., Drake, R.R., Gentry, M.S. (2021). Brain glycogen serves as a critical glucosamine cache required for protein glycosylation. Cell Metabolism. 33, 1-14. (Full Article)

Kinslow, C., Chaudhary, K., Upadhyayula, P., Wang, T., Sun, R.C., Cheng, S. (2021). Purine synthesis as a target for radiation resistance in molecular glioblastoma. Journal of the Neurological Sciences. 425, 117439. (Full Article)

Myint, Z.W., Sun, R.C., Hensley, P.J., James, A.C., Wang, P., Strup, S.E., McDonald, R.J., Yan, D., St. Clair, W.H., Allison, D.B. (2021). Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters. Cancers. 13, 13092157. (Full Article)

Duran, J., Hervera, A., Markussen, K.H., Verea, O., Lopes-Soldado, I., Sun, R.C., Antonio del Rio, J., Gentry, M.S., Guinovart, J.J. (2021). Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease. Brain. awab110. (Full Article)

Hepowit, N.L., Macedo, J.KA., Young, L.EA., Liu, K., Sun, R.C., MacGurn, J.A., Dickson, R.C. (2021). Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools. Aging. 13, 7846—7871. (Full Article)

 

Stanback, A.E., Conroy, L.R., Young, L.EA., Hawkinson, T.R., Markussen, K.H., Clarke, H.A., Allison, D.B., Sun, R.C. (2021). Regional N-glycan and lipid analysis from tissues using MALDI-mass spectrometry imaging. STAR Protocols. 2, 100304. (Full Article)

 

2020

Williams, H.C., Piron, M.A., Nation, G.K., Walsh, A.E., Young, L.EA., Sun, R.C., Johnson, L.A. (2020). Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics. Metabolites. 10, 501. (Full Article)

Andres, D.A., Young, L.EA., Gentry, M.S., Sun, R.C. (2020). Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging. Journal of Lipid Research. 61, 1537. (Full Article)

Kinslow, C.J., Sun, R.C., Chaudhary, K.R., Cheng, S.K. (2020). Serine and One-Carbon Metabolism in Breast Cancer Metastasis. Molecular Cancer Research. 18, 1755. (Full Article)

Gentry, M.S., Sun, R.C., Young, L.EA. (2020). Method of treating cancer with an elevated glycogen content. United States Patent Application Publication. US 2020/0215031 A1. (Full Text)

Donohue, K.J., Gentry, M.S., Sun, R.C. (2020). The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation. Annals of Translational Medicine​.

8, 254. (Full Article) 

Williams, H.C., Farmer, B.C., Piron, M.A., Walsh, A.E., Bruntz, R.C., Gentry, M.S., Sun, R.C., Johnson, L.A. (2020). APOE alters glucose flux through central carbon pathways in astrocytes. Neurobiology of Disease. 136, 104742. (Full Article) 

Andres, D.A., Young, L.EA., Veeranki, S., Hawkinson, T.R., Levitan, B.M., He, D., Wang, C., Satin, J., Sun, R.C. (2020). Improved workflow for mass spectrometry–based metabolomics analysis of the heart. Journal of Biological Chemistry. 295, 2676-2686. (Full Article)

Young, L.EA., Brizzee, C.O., Macedo, J.KA., Murphy, R.D., Contreras, C.J., DePaoli-Roach, A.A., Roach, P.J., Gentry, M.S., Sun, R.C. (2020). Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry. Carbohydrate Polymers. 230, 115651.

(Full Article)

Hepowit, N.L., Macedo, J.KA., Young, L.EA., Liu, K., Sun, R.C., MacGurn, J., Dickson, R.C. (2020). Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools. bioRxiv. 362459. (Full Article)

Farmer, B.C., Williams, H.C., Devanney, N.A., Piron, M.A., Nation, G.K., Carter, D.J., Walsh, A.E., Khanal, R., Young, L.EA., Kluemper, J.C., Hernandez, G., Allenger, E.J., Mooney, R., Brandon, J.A., Gupta, V.A., Kern, P.A., Gentry, M.S., Morganti, J.M., Sun, R.C., Johnson, L.A. (2020). APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis. bioRxiv. 345991. (Full Article)

Conroy, L.R., Young, L.EA., Stanback, A.E., Austin, G.L., Liu, Jp., Liu, Jz., Allison, D.B., Sun, R.C. (2020). Mass Spectrometry Imaging of N-Glycans Reveals Racial Discrepancies in Low Grade Prostate Tumors. bioRxiv. 260026. (Full Article)

Conroy, L.R., Dougherty, S., Kruer, T., Metcalf, S., Lorkiewicz, P., He, L., Yin, X., Zhang,X., Arumugam, S.,Young, L.EA., Sun, R.C., Clem, B.F. (2020). Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven Lung Tumors In Vivo. Cancers. 12, 237. (Full Article)

Zhou, Z., Kinslow, C.J., Wang, P., Huang, B., Cheng, S.K., Deutsch, I., Gentry, M.S., Sun, R.C. (2020). Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis. Journal of Clinical Medicine​. 9, 138. (Full Article) 

2019

Sun, R.C., Dukhande, V.V., Zhou, Z., Young, L.EA., Emanuelle, S., Brainson, C.F., Gentry, M.S. (2019). Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers. Cell Metabolism. 30, 903-916. e7. (Full Article) 

Gentry, M.S., Brewer, M.K., Uittenbogaard, A., Austin, G.L., Segvich, D.M., DePaoli-Roach, A., Roach, P.J., McCarthy, J.J., Simmons, Z.R., Brandon, J.A., Zhou, Z., Zeller, J., Young, L.EA., Sun, R.C., Pauly, J.R., Aziz, N.M., Hodges, B.L., McKnight, T.R., Armstrong, D.D. (2019). Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion. Cell Metabolism​. 30, 689-705. (Full Article)

Zhou, Z., Kinslow, C.J., Hibshoosh, H., Guo, H., Cheng, S.K., He, C., Gentry, M.S., Sun, R.C. (2019). Clinical Features, Survival and Prognostic Factors of Glycogen-Rich Clear Cell Carcinoma (GRCC) of the Breast in the U.S. Population. Journal of Clinical Medicine. 8, 246. (Full Article)

2018

Zhou, Z., Austin, G.L., Young, L.EA., Johnson, L.A., Sun, R.C. (2018). Mitochondrial Metabolism in Major Neurological Diseases. Cells. 7, 229. (Full Article)

Deng, P., Higashi, R.M., Lane, A.N., Bruntz, R.C., Sun, R.C., Ramakrishnam Raju, M.V., Nantz, M.H., Qi, Z., Fan, T. W-M. Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS. Analyst. 143, 311. 

2017

Deng, P., Higashi, R.M., Lane, A.N., Bruntz, R.C., Sun, R.C., Ramakrishnam Raju, M.V., Nantz, M.H., Qi, Z., Fan, T. W-M. (2017). Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS†. Analyst. 143, 311-322. (Full Article)

Sun, R.C., Fan, T.W-M., Deng, P., Higashi, R.M., Lane, A.N., Le, A-T., Scott, T.L., Sun, Q., Warmoes, M.O., Yang, Y. (2017). Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing. Nature Communications. 8, 1-10. (Full Article)

Fan, T.W., Sun, R.C., Warmoes, M.O., Sun, Q., Song, H., Mahan, A., Martin, J., Higashi, R.M., Lane, A.N. (2017). Abstract SY02-02: Exploring the lung cancer metabolome, in vivo and ex vivo, for individualized medicine. Cancer Research. 77, SY02-02-SY02-02. (Full Article)

Sun, R.C., Warmoes, M.O., Yang, Y., Deng, P., Sun, Q., Lane, A.N., Higashi, R.M., Fan, T.W-M.. (2017). Liquid diet introduction of tracers into mice for stable isotope-resolved metabolomics (SIRM) investigations. Cancer Research. 77, 2502-2502. (Full Article)

2016

Golias, T., Papandreou, I., Sun, R.C, Kumar, B., Brown, N.V., Swanson, B.J., Pai, R., Jaitin, D., Le, Q-T., Teknos, T.N., Denko, N.C. (2016). Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours. Scientific Reports​. 6, 31146. (Full Article)

Sun, R.C., Koong, A., Giaccia, A., Denko, N. (2016). Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells. Tumor Microenvironment : Study Protocols.  1, 113-120. (Full Article)

2015

O'Neill, W., Sun, R.C., Papandreou, I., Kalmar, J., Denko, N. (2015). Construction of a Fluorescent Reporter Gene for the Analysis of OGDH2 Protein Stability in Hypoxia. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 120, e146. (Full Article)

Cerniglia, G.J., Dey, S., Gallagher-Colombo, S.M., Daurio, N.A., Tuttle, S., Busch, T.M., Lin, A., Sun, R.C., Esipova, T.V., Vinogradov, S.A., Denko, N., Koumenis, C., Maity, A. (2015). The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation. Molecular Cancer Therapeutics. 14, 1928-1938. (Full Article)

Maity, A., Cerniglia, G.J., Dey, S., Gallagher-Colombo, S.M., Daurio, N., Tuttle, S., Busch, T.M., Sun, R.C., Denko, N., Lin, A., Koumenis, C. (2015). SP-0541: The PI3K/mTOR pathway regulates oxygen metabolism via pyruvate dehydrogenase (PDH)-E1a phosphorylation. Radiotherapy and Oncology. 115, S261. (Full Article)

2014

Sun, R.C., Denko, N.C. (2014). Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth. Cell Metabolism. 19, 285-292. (Full Article)

2011

Sun, R.C., Board, P.G., Blackburn, A.C. (2011). Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells. Molecular Cancer. 10, 1-15. (Full Article)

2010

Sun, R.C., Fadia, M., Dahlstrom, J.E., Parish, C.R., Board, P.G., Blackburn, A.C. (2010). Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo. Breast Cancer Research and Treatment​. 120, 253-260. (Full Article)

Blackburn, A.C., Rooke, M., Sun, R.C., Fadia, M., Dahlstrom, J.E., Board, P.G. (2010). Reversal of the glycolytic phenotype with dichloroacetate in a mouse mammary adenocarcinoma model. Pathology. 42, S61-S62. (Full Article)

2009

Sun, R.C., Board, P.G., Blackburn, A.C. (2009). New drug combinations to target the Warburg effect in cancer therapy. American Association for Cancer Research. 69, 615. (Full Article)