Publications

2021

Gentry NG, Markussen KH, Sun R.C, Vander Kooi CW. (2021). Treatment of Lafora disease with an antibody-enzyme fusion. Jasper's Basic Mechanisms of the Epilepsies 5th edition. In Press. 

 

Lindsey R Conroy, Derek B Allison, Qi Sun, Lyndsay EA Young, Tara R Hawkinson, Harrison A Clarke, Juanita E Ferreira, Autumn V Hammonds, Robert J McDonald, Kimberly J Absher, Warren J Alilain, Christopher M Waters, Jinze Liu, Ramon C Sun. (2021). Multi-Dimensional Reduction Clustering of Complex Carbohydrates Reveal Tissue Metabolism, Heterogeneity and Histopathology. bioRxiv.  (Full Article)

Lindsey R Conroy, Alexandra E Stanback, Lyndsay E.A Young, Harrison A Clarke, Grant L Austin, Jinze Liu, Derek B Allison, Ramon C Sun. (2021). In situ analysis of N-linked Glycans as Potential Biomarkers of Clinical Course in Human Prostate Cancer. Molecular Cancer Research. (Full Article)

Ramon C. Sun, Lyndsay E.A. Young, Ronald C. Bruntz, Kia H. Markussen, Zhengqiu Zhou, Lindsey R. Conroy, Tara R. Hawkinson, Harrison A. Clarke, Alexandra E. Stanback, ....... ,Christine F. Brainson, Lance A. Johnson, Richard E. Taylor, Dustin D. Armstrong, Robert Shaffer, Charles J. Waechter, Craig W. Vander Kooi, Anna A. DePaoli-Roach, Peter J. Roach, Thomas D. Hurley, Richard R. Drake, Matthew S. Gentry. (2021). Brain glycogen serves as a critical glucosamine cache required for protein glycosylation. Cell Metabolism. 33, 1-14. (Full Article)

Hawkinson, T.R., Sun R.C. (2021). Mass Spectrometry Imaging of Glycogen In Situ. In Press, Methods in Molecular Biology

Kinslow C., Chaudhary K, Upadhyayula P., Wang T., Sun R.C., Cheng S (2021). Purine synthesis as a target for radiation resistance in molecular glioblastoma. Journal of the Neurological Sciences. 425, 117439. (Full Article)

Myint Z.W., Sun R.C., Hensley P.J., James A.C., Wang P., Strup S.E., McDonald R.J., Yan D., St. Clair W.H., Allison D.B. (2021). Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters. Cancers. 13, 13092157. (Full Article)

Jordi Duran, Arnau Hervera, Kia H. Markussen, Olga Verea, Iliana Lopes-Soldado, Ramon C Sun, Jose Antonio del Rio, Mathew S Gentry, Joan J Guinovart. (2021). Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease. Brain. awab110. (Full Article)

Nathaniel L. Hepowit, Jessica K. A. Macedo, Lyndsay E. A. Young, Ke Liu, Ramon C Sun,  Jason A. MacGurn, Robert C. Dickson. (2021). Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools. Aging. 13, 7846—7871. (Full Article)

 

Alexandra E Stanback, Lindsey R Conroy, Lyndsay EA Young, Tara R Hawkinson, Kia H Markussen, Harrison A Clarke, Derek B Allison, Ramon C Sun. (2021). Regional N-glycan and lipid analysis from tissues using MALDI-mass spectrometry imaging. STAR Protocols. 2, 100304. (Full Article)

 

2020

Holden C Williams, Margaret A Piron, Grant K Nation, Adeline E Walsh, Lyndsay EA Young, Ramon C Sun, Lance A Johnson. (2020). Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics. Metabolites. 10, 501. (Full Article)

Douglas A Andres, Lyndsay EA Young, Matthew S Gentry, Ramon C Sun. (2020). Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging. Journal of lipid research. 61, 1537. (Full Article)

Connor J Kinslow, Ramon C Sun, Kunal R Chaudhary, Simon K. Cheng. (2020). Serine and One-Carbon Metabolism in Breast Cancer Metastasis. Molecular Cancer Research. 18, 1755. (Full Article)

Matthew S Gentry, Ramon C Sun, Lyndsay EA Young. (2020). Method of treating cancer with an elevated glycogen content. United States Patent Application Publication. US 2020/0215031 A1. (Full Text)

KJ Donohue, MS Gentry, Ramon C Sun. (2020). The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation. Annals of Translational Medicine​.

8, 254. (Full Article) 

Holden C Williams, Brandon C Farmer, Margaret A Piron, Adeline E Walsh, Ronald C Bruntz, Matthew S Gentry, Ramon C Sun, Lance A Johnson. (2020). APOE alters glucose flux through central carbon pathways in astrocytes. Neurobiology of disease. 136, 104742. (Full Article) 

Douglas A Andres, Lyndsay EA Young, Sudhakar Veeranki, Tara R Hawkinson, Bryana M Levitan, Daheng He, Chi Wang, Jonathan Satin, Ramon C Sun. (2020). Improved workflow for mass spectrometry–based metabolomics analysis of the heart. Journal of Biological Chemistry. 295, 2676-2686. (Full Article)

Lyndsay EA Young, Corey O Brizzee, Jessica KA Macedo, Robert D Murphy, Christopher J Contreras, Anna A DePaoli-Roach, Peter J Roach, Matthew S Gentry, Ramon C Sun. (2020). Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry. Carbohydrate polymers. 230, 115651.

(Full Article)

Nathaniel L Hepowit, Jessica KA Macedo, Lyndsay EA Young, Ke Liu, Ramon C Sun, Jason MacGurn, Robert C Dickson. (2020). Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools. bioRxiv. 362459. (Full Article)

Brandon C Farmer, Holden C Williams, Nicholas A Devanney, Margaret A Piron, Grant K Nation, David J Carter, Adeline E Walsh, Rebika Khanal, Lyndsay EA Young, Jude C Kluemper, Gabriela Hernandez, Elizabeth J Allenger, Rachel Mooney, J Anthony Brandon, Vedant A Gupta, Philip A Kern, Matthew S Gentry, Josh M Morganti, Ramon C Sun, Lance A Johnson. (2020). APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis. bioRxiv. 345991. (Full Article)

Lindsey R Conroy, Lyndsay EA Young, Alexandra E Stanback, Grant L Austin, Jinpeng Liu, Jinze Liu, Derek B Allison, Ramon C Sun. (2020). Mass Spectrometry Imaging of N-Glycans Reveals Racial Discrepancies in Low Grade Prostate Tumors. bioRxiv. 260026. (Full Article)

Lindsey R Conroy, Susan Dougherty, Traci Kruer, Stephanie Metcalf, Pawel Lorkiewicz, Liqing He, Xinmin Yin, Xiang Zhang, Sengodagounder Arumugam, Lyndsay EA Young, Ramon C Sun, Brian F Clem. (2020). Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven Lung Tumors In Vivo. Cancers. 12, 237. (Full Article)

Zhengqiu Zhou, Connor J Kinslow, Peng Wang, Bin Huang, Simon K Cheng, Israel Deutsch, Matthew S Gentry, Ramon C Sun. (2020). Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis. Journal of clinical medicine​. 9, 138. (Full Article) 

2019

Ramon C Sun, Vikas V Dukhande, Zhengqiu Zhou, Lyndsay EA Young, Shane Emanuelle, Christine Fillmore Brainson, Matthew S Gentry. (2019). Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers. Cell metabolism. 30, 903-916. e7. (Full Article) 

Gentry MS. Brewer MK, Uittenbogaard A, Austin GL, Segvich DM, DePaoli-Roach A, Roach PJ, McCarthy JJ, Simmons ZR, Brandon JA, Zhou Z, Zeller J, Young LEA, Sun RC, Pauly JR, Aziz NM, Hodges BL, McKnight TR, Armstrong DD. (2019). Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion. Cell Metabolism​. 30, 689-705. (Full Article)

Zhengqiu Zhou, Connor J Kinslow, Hanina Hibshoosh, Hua Guo, Simon K Cheng, Chunyan He, Matthew S Gentry, Ramon C Sun. (2019). Clinical Features, Survival and Prognostic Factors of Glycogen-Rich Clear Cell Carcinoma (GRCC) of the Breast in the U.S. Population. Journal of clinical medicine. 8, 246. (Full Article)

2018

Zhengqiu Zhou, Grant L Austin, Lyndsay EA Young, Lance A Johnson, Ramon C Sun. (2018). Mitochondrial Metabolism in Major Neurological Diseases. Cells. 7, 229. (Full Article)

Pan Deng, Richard M Higashi, Andrew N Lane, Ronald C Bruntz, Ramon C Sun, Mandapati V Ramakrishnam Raju, Michael H Nantz, Zhen Qi, Teresa W-M Fan. Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS. Analyst. 143, 311. 

2017

Pan Deng, Richard M Higashi, Andrew N Lane, Ronald C Bruntz, Ramon C Sun, Mandapati V Ramakrishnam Raju, Michael H Nantz, Zhen Qi, Teresa W-M Fan. (2017). Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS†. Analyst. 143, 311-322. (Full Article)

Ramon C Sun, Teresa W-M Fan, Pan Deng, Richard M Higashi, Andrew N Lane, Anh-Thu Le, Timothy L Scott, Qiushi Sun, Marc O Warmoes, Ye Yang. (2017). Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing. Nature communications. 8, 1-10. (Full Article)

Teresa W Fan, Ramon Sun, Marc Warmoes, Qiushi Sun, Huan Song, Angela Mahan, Jeremiah Martin, RICHARD M Higashi, Andrew N Lane. (2017). Abstract SY02-02: Exploring the lung cancer metabolome, in vivo and ex vivo, for individualized medicine. Cancer Research. 77, SY02-02-SY02-02. (Full Article)

Ramon C Sun, Marc O Warmoes, Ye Yang, Pan Deng, Qiushi Sun, Andrew N Lane, Richard M Higashi, Teresa WM Fan. (2017). Liquid diet introduction of tracers into mice for stable isotope-resolved metabolomics (SIRM) investigations. Cancer Research. 77, 2502-2502. (Full Article)

2016

Tereza Golias, Ioanna Papandreou, Ramon Sun, Bhavna Kumar, Nicole V Brown, Benjamin J Swanson, Reetesh Pai, Diego Jaitin, Quynh-Thu Le, Theodoros N Teknos, Nicholas C Denko. (2016). Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours. Scientific reports​. 6, 31146.

(Full Article)

Ramon Sun, Albert Koong, Amato Giaccia, Nicolas Denko. (2016). Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells. Tumor Microenvironment : Study Protocols. 1, 113-120. (Full Article)

2015

Wendi O'NEILL, R SUN, I PAPANDREOU, J KALMAR, N DENKO. (2015). Construction of a Fluorescent Reporter Gene for the Analysis of OGDH2 Protein Stability in Hypoxia. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 120, e146. (Full Article)

George J Cerniglia, Souvik Dey, Shannon M Gallagher-Colombo, Natalie A Daurio, Stephen Tuttle, Theresa M Busch, Alexander Lin, Ramon Sun, Tatiana V Esipova, Sergei A Vinogradov, Nicholas Denko, Constantinos Koumenis, Amit Maity. (2015). The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation. Molecular cancer therapeutics. 14, 1928-1938. (Full Article)

A Maity, GJ Cerniglia, S Dey, SM Gallagher-Colombo, N Daurio, S Tuttle, TM Busch, R Sun, N Denko, A Lin, C Koumenis. (2015). SP-0541: The PI3K/mTOR pathway regulates oxygen metabolism via pyruvate dehydrogenase (PDH)-E1a phosphorylation. Radiotherapy and Oncology. 115, S261. (Full Article)

2014

Ramon C Sun, Nicholas C Denko. (2014). Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth.

Cell metabolism. 19, 285-292. (Full Article)

2011

Ramon C Sun, Philip G Board, Anneke C Blackburn. (2011). Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells. Molecular cancer. 10, 1-15.

(Full Article)

2010

Ramon C Sun, Mitali Fadia, Jane E Dahlstrom, Christopher R Parish, Philip G Board, Anneke C Blackburn. (2010). Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo. Breast cancer research and treatment​. 120, 253-260. (Full Article)

Anneke C Blackburn, Melissa Rooke, Ramon C Sun, Mitali Fadia, Jane E Dahlstrom, Philip G Board. (2010). Reversal of the glycolytic phenotype with dichloroacetate in a mouse mammary adenocarcinoma model. Pathology. 42, S61-S62. (Full Article)

2009

Ramon Sun, Philip Board, Anneke Blackburn. (2009). New drug combinations to target the Warburg effect in cancer therapy. American Association for Cancer Research. 69, 615.