My lab focuses on deciphering the molecular events connecting glycogen metabolism to cellular metabolism, signaling, and physiology, with a strong emphasis on the progression of neurodegenerative diseases and Glycogen-rich class of cancer.
My scientific philosophy is that I want to find true, clinically relevant and widely applicable mechanisms of disease. Therefore, my lab employs multiple models, from cell-free to animal models, multiple techniques, including metabolomics, histology, genetic manipulations, and pharmacological approaches to tackle complex biological questions
Oligosaccharide Metabolism in Neurological Disorders
We aim to solve the metabolic dynamic between glycogen and N-glycans, the molecular events leading to their dysregulation, and the contribution of perturbed glycosylation and glycogen in neurological disorders.
Our lab established a unique combination workflow of targeted metabolomics using gas-chromatography, liquid-chromatography, capillary-electrophoresis, MALDI, and DESI mass spectrometry coupled to inhouse high throughput software with rigorous quality control and normalization steps to study perturbations in metabolism.
MALDI Mass Spectrometry Imaging
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI Imaging) has entered the field of tissue-based research by providing unique advantages for analyzing tissue specimens in unprecedented detail. A broad spectrum of analytes ranging from proteins, peptides, protein modification, small-molecule metabolites, drugs, and their metabolites, as well as pharmaceutical components, lipids, and other analytes, are accessible by this in situ technique.
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