Research Direction

My lab focuses on deciphering the molecular events connecting glycogen metabolism to cellular metabolism, signaling, and physiology, with a strong emphasis on the progression of neurodegenerative diseases and Glycogen-rich class of cancer.

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Our Research

My scientific philosophy is that I want to find true, clinically relevant and widely applicable mechanisms of disease. Therefore, my lab employs multiple models, from cell-free to animal models, multiple techniques, including metabolomics, histology, genetic manipulations, and pharmacological approaches to tackle complex biological questions

  • De novo synthesized glycogen accumulates in the nucleus of non-small cell lung cancers

  • Nuclear glycogen provides a carbon pool for histone acetylation

  • Nuclear glycogenolysis is dependent on translocation of glycogen phosphorylase

  • Glycogen phosphorylase translocation is regulated by the E3 ubiquitin ligase malin

Our Methodologies

Our lab established a unique combination workflow of targeted metabolomics using gas-chromatography, liquid-chromatography, capillary-electrophoresis, MALDI, and DESI mass spectrometry coupled to inhouse high throughput software with rigorous quality control and normalization steps to study perturbations in metabolism.

Our Funding Sources
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MALDI Mass Spectrometry Imaging

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI Imaging) has entered the field of tissue-based research by providing unique advantages for analyzing tissue specimens in unprecedented detail. A broad spectrum of analytes ranging from proteins, peptides, protein modification, small-molecule metabolites, drugs, and their metabolites, as well as pharmaceutical components, lipids, and other analytes, are accessible by this in situ technique.

News & Resources

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