We study intrinsic (genetic polymorphism, somatic mutations, in-born errors in metabolism) and extrinsic factors (breathing, diet, exercise) influencing lung metabolism, biology, and physiology. We employ transdisciplinary techniques including epigenetics, molecular biology, metabolomics, spatial imaging, and physiological assays to study metabolic underpinnings of organismal complexity.
MALDI Mass Spectrometry Imaging
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI Imaging) has entered the field of tissue-based research by providing unique advantages for analyzing tissue specimens in unprecedented detail. A broad spectrum of analytes ranging from proteins, peptides, protein modification, small-molecule metabolites, drugs, and their metabolites, as well as pharmaceutical components, lipids, and other analytes, are accessible by this in situ technique.